Form of release of medicine. Tablets on 0,025 g, powder.
Use and doses of drug. Inside after food on 0,01 — 0,025 g of 1 — 2 — 3 time a day, sometimes to 0,15 g a day; in an eye on 2 drops of 5% of solution.
Treatment is begun with a small dose, gradually increasing it before receiving therapeutic effect; further the dose is gradually reduced and continue treatment by small maintenance doses for a long time. The patient of advanced age appoint 1/4 tablets of 1 times a day in the beginning, and then on 0,025 — 0,05 g a day.
Effect of the medicine. Selectively collects in postganglionic sympathetic nerves and causes "release" from depot of catecholamines (adrenaline and noradrenaline), i.e. mediators of sympathetic nerve fibrils therefore transfer of centrifugal, vasoconstrictive impulses is broken. Disturbance of a centrifugal impulsation in sympathetic nerves brings in the basic to long strong lowering of arterial pressure. Octadinum slows down a cordial rhythm, lowers venous pressure, reduces peripheric resistance. Noticeable lowering of arterial pressure in an initiation of treatment can cause reduction of a renal blood-groove and filtrational function of kidneys. Further these indicators are normalized. Action of Octadinum is shown in 2 — 4 days after an initiation of treatment and reaches a maximum on 7 — the 8th day. After the termination of introduction of Octadinum within 1 — 2 weeks hypotension proceeds. Causes decrease in intraocular pressure in patients with an open chamber corner and in glaucoma combination cases to an idiopathic hypertensia. Octadinum is well soaked up and has advantage before gangliolytic drugs: does not give cholinolytic effect (a lock, paralytic impassability of guts, a vision disorder etc.; see Atropine), has the expressed long hypotensive effect.
Indications to use. An idiopathic hypertensia of I, II and III stages, including severe forms with permanent increase of arterial pressure and with a malignant current; glaucoma with an open chamber corner, allergic reactions.
Contraindications. Pheochromocytoma, atherosclerosis, myocardial infarction; diseases of kidneys with the expressed insufficiency of function, hypotension, an acute disorder of cerebral circulation.
Possible by-effects. The general weakness, an adynamia, dizziness, nausea, vomiting, swelling of a mucous membrane of a nose, pain in a parotid gland, a diarrhea, a liquid delay fabrics, disturbance of an ejaculation, increase in fluctuations of arterial pressure within a day, orthostatic hypotension, an orthostatic collapse. Due to the last it is recommended to begin treatment with Octadinum in a hospital.
Treatment of complications and poisonings. See Methyldopa.