Farmakoterapevtichesky group. Antimicrobic means for system use. Ftorkhinolona. Code of automatic telephone exchange J01MA01.
Effect of the medicine. Pharmacodynamics. Ofloxacin – synthetic antimicrobic drug of the fluorinated hinolon of a broad spectrum of activity.
In the concentration identical to the minimum overwhelming concentration (M_S), or in a little highest, he shows bactericidal action (by braking DNK-girazy – the enzyme necessary for duplication and a transcription of bacterial DNA).
The antimicrobic range covers gram-negative and gram-positive bacteria, are sensitive to an ofloksatsin: Enterobacteriaceae (Escherichia coli, types of Citrobacter, Enterobacter, Klebsiella, Proteus, Providencia, Salmonella, Serratia, Shigella, Yersinia), Pseudomonas spp., including Pseudomonas aeruginosa, Haemophilus influenzae, Haemophilus ducreyi, Branhamella catarrhalis, Neisseria gonorrhoeae, Neisseria meningitidis, Acinetobacter spp., Campylobacter spp., Gardnerella vaginalis, Helicobacter pylori, Pasteurella multocida, Vibrio spp., Brucella melitensis; staphylococcus, including strains that develop a penicillinase, and some strains, resistant to Methicillinum; also it has activity concerning Chlamydia trachomatis, Chlamydia pneumoniae, Mycoplasma pneumoniae, Ureaplasma urealyticum (at the M_S boundary values), Mycobacterium tuberculosis, Mycobacterium leprae and some other mycobacteria.
Sensitivity of streptococci of group A, B and C is boundary.
The majority of anaerobe bacterias, except for Clostridium perfringens, is resistant.
Ofloxacin inactive Treponema pallidum is relative.
Pharmacokinetics. After internal use ofloxacin is quickly absorbed from a digestive tract. Biological availability of drug makes 96-100%. The maximum concentration in a blood plasma is noted in 1-2 hours. Linkng with proteins of plasma makes 25%. The elimination half-life is equal to 5-8 hours. To 80% of drug it is removed by kidneys in an invariable look, breaks up to 5% of a dose. At patients with a renal or liver failure allocation of an ofloksatsin from an organism can be slowed down. Drug easily gets through a placenta and gets to maternal milk.
Indications for use. The infectious and inflammatory diseases caused by microorganisms, sensitive to Ofloksin, including:
- infectious and inflammatory respiratory diseases;
- infectious and inflammatory diseases of an ear, throat, nose;
- infectious and inflammatory diseases of skin, soft tissues, bones, joints;
- infectious and inflammatory diseases of abdominal organs and small pelvis;
- infectious and inflammatory diseases of kidneys and urinary tract, generative organs (including gonorrhea).
Way of use and dose. The mode of a dosage is defined by the doctor individually and depends on weight and a type of an infection. The daily dose makes from 200 to 800 mg at average durations of treatment of 7-10 days. The adult appoint 1-2 tablets 2 times a day or 2-4 tablets "Ofloksina 200" once a day.
The maximum daily dose – 800 mg.
For patients with heavy abnormal liver functions the daily dose should not exceed 400 mg.
For patients with a renal failure the dose of drug depends on the clearance of creatinine (CC). At KK of 20-50 ml/minutes the first dose makes 200 mg, then – on 100 mg every 24 hour; at KK less than 20 ml/minutes the first dose – 200 mg, and then – on 100 mg every 48 hours.
Drug should be used in 30-60 minutes prior to food, washing down with a small amount of liquid.
In a case the admission of reception of a dose needs to accept drug at once after remembered; possible concomitant use of all daily dose.
Side effect. From a digestive tract the dispepsichesky phenomena – anorexia, nausea, vomiting, diarrhea, an abdominal pain are possible, it is rare – tranzitorny increase of level of liver enzymes of blood, bilirubin, development of pseudomembranous colitis is possible.
From the hemopoietic system anemia, a leukopenia, a neutropenia, an agranulocytosis, thrombocytopenia are possible.
From the central nervous system delay of speed of reactions, a headache, dizziness, a sleep disorder, concern, excitement, a hallucination are possible.
From sense bodys: seldom – a vision disorder, taste, to a scent.
From kidneys: tranzitorny disturbance of secretory function with increase of level of urea, creatinine.
Contraindications. Hypersensitivity to an ofloksatsin and other hinolonovy drugs, epilepsy, defeats of TsNS with a reduced convulsive threshold, pregnancy, a lactation.
Children's age till 15 flyings.
Overdose. Overdose symptoms: dizziness, misting of consciousness, block, vomiting. Treatment is symptomatic and auxiliary, with concentration of attention on ensuring the vital functions. Ofloxacin is removed generally by kidneys (75-80% of the entered dose are removed in not changed state together with urine within 24-48 hours), its elimination can be accelerated by the forced volume diuresis. Only in the ofloxacin limited quantities it is possible to remove from an organism with a hemodialysis (on average 15-25%) or a peritoneal dialysis (less than 2%).
Features of use. During treatment the use of alcoholic drinks is not recommended. Ofloksin's use 200 can negatively influence work performance that demands the increased speed of mental and physical reactions (control of vehicles, mechanisms, work at height, etc.).
During treatment patients should not give in to ultra-violet radiation.
With care appoint at atherosclerosis of vessels of a brain, disturbance of cerebral circulation, a renal failure.
Interaction with other medicines. The concomitant use of antiacid means leads to decrease in efficiency of drug. Simultaneous use of Ofloksin of 200 and nonsteroid antirheumatic drugs increases probability of emergence of spasms.
Medicines that reduce acidity of a gastric juice, contain magnesium, aluminum, iron or zinc, it is necessary to accept in 2 hours prior to or in 2 hours after Ofloksin's reception 200.
Conditions and periods of storage. To store in the unavailable to children, dry, protected from action of light place at a temperature of 10-25 °C. A period of validity – 3 years.