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Crysanolum

Crysanolum. Crysanolum. Oleochrysine.

Structure: mix of 70% of aurotiopropanol-sulphonate of calcium and 30% of a gluconate of calcium, contains 33,5% of gold.

Form of release of medicine. Ampoules on 2 ml of 5 and 10% of a suspension in oil.

Use and doses of drug. Intramusculary after warming up on 2 ml of 5% of a suspension of 10 bucketed injections for 2 — 5 days. Then on 2 ml of 10% of a suspension of 10 injections with the same intervals. Concentration of gold in blood serum should not exceed 250 — 300 mkg / 100 ml. A course of treatment — 1 1/2 — 2 years. At the same time appoint non-steroidal anti-inflammatory drugs.

Effect of the medicine. Crysanolum increases cross bonds between collagenic fibers, condenses synovial membranes, oppresses lizosomalny enzymes, transaminase and formation of glikozamino-6-phosphate in connecting fabric. Has antimicrobic effect.

Indications to use. Pseudorheumatism, lupus erythematosus.

Contraindications. Diseases of kidneys, diabetes, the decompiled heart diseases, a cachexia, miliary tuberculosis, fibrous and cavernous processes in lungs, treatment by corticosteroids.

Possible by-effects. Nephropathy, dermatitis, stomatitis, diarrhea, agranulocytosis, encephalitis, neuritis, hepatitis, advanced age.

Treatment of complications and poisonings. Antidotes — Unithiolum, Penicillaminum. To cancel drug. In the presence of skin manifestations appoint antihistaminic drugs, corticosteroids (rezorbtivno or locally).

 
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