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Galavit suppositories

Galavit suppositories (Galavit suppositories)

the name is chemical: 5-амино-1,2,3,4-тетрагидрофталазин-1,4-диона sodium salt;

Main physical and chemical characteristics: suppositories from color of a torpedopodobny form, white to white with a yellowish shade;

sostav:1 suppository Galavita includes 0,1 g;

other components: vitepsol H15, vitepsol W35.

Form of release of medicine. Suppositories rectal.

Farmakoterapevtichesky group. Cytokines and immunomodulators.

Code of automatic telephone exchange L03A ò 15 **.

Effect of the medicine.

Pharmacodynamics.

Drug has antiinflammatory and immunnomodeliruyushchy properties. His main action is caused by ability to work on functional and metabolic activity of macrophages.

At inflammatory diseases drug back for 6 – 8 hours inhibits excessive synthesis of a factor of a necrosis of tumors, interleykina-1, active forms of oxygen hyper elicited macrophages which define extent of inflammatory reactions, their recurrence, and also expressiveness of intoxication. Normalization of a functional condition of macrophages to lead to decrease in an autoaggression and resuming of function of T lymphocytes.

At the same time drug stimulates microbicidal activity of neutrocytes, strengthens phagocytosis, has antioxidant and anti-diarrheal action, stimulates interferon synthesis an alpha and scale, regulates a reparation of fabrics, reduces formations of hems when healing, increases nonspecific resistance of an organism to infectious diseases.

Farmakodinamichesky effects are observed within 72 hours.

Pharmacokinetics. Drug is quickly removed from an organism, generally by kidneys. After rectal use half-life makes 60 – 70 minutes.

Indications for Galavit's use. As an immunomodulator in complex therapy of such diseases:

- acute and chronic diseases of a gastrointestinal tract (peptic ulcer of a stomach and duodenum, damage of a liver of a different etiology, including hepatitises B and C, gastroenteritis);

- pathogenetic treatment of acute infectious diseases (intestinal infections, purulent meningitis, sepsis, beshikh, pneumonia);

- diseases of an urogenital path (genital herpes, tsitomegalovirusny infection, clamidiosis, mycoplasmosis, hysteromyoma, prostate adenoma);

- it is purulent - septic processes in before - and the postoperative period and for prevention of infectious surgical complications;

- hronichesko recurrent herpes infection;

- chronic recurrent furunculosis;

- chronic inflammatory diseases which arose against secondary immunological insufficiency;

- immunocorrection and immunorehabilitation at oncological diseases: the disseminated breast cancer of the III stage, lung cancer of the III stage (as a part of a complex himio-and radiation therapy).

Way of use and dose.

Suppositories release from a blister strip packaging and then enter into a rectum. Before it it is recommended to vyporozhnit intestines.

The dose and duration use of drug depends on weight and duration of a disease.

At infectious diseases of a different etiology (including septic states, hepatitises B and C, meningitis) an initial dose for adults – 0,2 g. Then pass to administration of drug on 0,1 g 2 – 3 times a day before elimination of symptoms of intoxication and an inflammation, then perhaps continuations of a course of therapy in a dose of 0,1g 1 times in 2 – 3 days. Duration of a course depends on a condition of the patient and can make up to 25 suppositories.

At gastrointestinal tract diseases (a peptic ulcer, nonspecific ulcer colitis, an illness Krone) and urinogenital system the initial dose for adults during the acute period makes 0,2 g of 1 times a day, within 1 – 2 days, then pass to administrations of drug on 0,1 g of 1 times in 2 – 3 days. The course makes 15 – 25 suppositories of Galavit depending on a condition of the patient.

At a hysteromyoma appoint 0,1 g a day daily within 5 days, further on 0,1 g of 1 times in 2 – 3 days. Course of treatment of 15 - 20 suppositories.

At prostate adenoma drug is appointed daily on 0,1 g a day within 5 days, further on 0,1 g of 1 times in 2 – 3 days.

At it is purulent - septic processes in before - and the postoperative period, and also for prevention of postoperative infectious complications by the adult appoint before or after operation on 0,1 g of drug within 5 days, then on 0,1 g every other day 5 suppositories, further on 0,1 g in 72 hours once a day; course of-15 suppositories.

At a chronic recurrent furunculosis: the adult in the first 5 days on 0,1 g

1 time in days of every day, then on 0,1 every other day. A course of treatment – to 20 suppositories.

At a persistent retsidiviruyushchiy herpes infection: the adult in the first 10 days on

0,1 g of 1 times a day, then on 0,1 g every other day. A course – to 25 suppositories.

At chronic inflammatory diseases which arose against immunodeficiency of the adult appoint on 0,1 g of 1 times in 3 days or 0,1 g of every day within 5 days, further 1 time in 2 – 3 days. The general course – 20 suppositories.

For immunocorrection at oncological diseases: a breast cancer of the III stage, lung cancer of the III stage (in a complex with himio-and radiation therapy) for adults an initial dose of 0,1 g every other day – 5 suppositories, then on 0,1 g with an interval of 72 hours. A course 20 – 30 suppositories.

Side effect. Side effects are not revealed.

Contraindications. Hypersensitivity to drug, pregnancy, a lactation.

Overdose. Till the current time about cases of overdose of drug of Galavit it was not reported.

Features of use. There is no experience of use for treatment of children.

Interaction with medicines. It is not described.

Conditions and periods of storage. To store in dry, protected from light, the place, unavailable to children, at a temperature from 5 to 12 degrees of Page. A period of validity – 2 years.

 
"Galavit   Galium-Hel"