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Apoptosis at chronic heart failure

Chronic heart failure: apoptosis of cardiomyocytes (I)

Apoptosis - the all-biological mechanism of "natural death" (self-elimination) of a cell.
Unlike a necrosis ("violent" death of a cell) is process:
a) volatile,
b) actively adjustable cellular
genetic device,
c)  strictly regulated in time

 

Апоптоз

Chronic heart failure: apoptosis of cardiomyocytes (II)

Physiological: the annual death of cardiomyocytes makes 45x106 and 19x106 for the left and right ventricles respectively

Pathological: has character, catastrophic for a myocardium, - intensity of death of cardiomyocytes exceeds control sizes by 230 times (P. Anversa, 1998)
апоптоз кардиомиоцитов (II)


* NUP - natriuretic peptides

 

Chronic heart failure: apoptosis of cardiomyocytes (III)

Why in dekompensirovanny heart the cardiomyocyte easily reacts to apoptotic incentives?
апоптоз кардиомиоцитов (III)

Chronic heart failure: apoptosis of cardiomyocytes (IV)


апоптоз кардиомиоцитов (IV)

Chronic heart failure: apoptosis of cardiomyocytes (V)

Differences of apoptosis from a necrosis:

  1. lack of primary loss of integrity of a cellular membrane
  2. lack of inflammatory reaction
  3. absence of replaceable fibrosis

Apoptosis - the leading reason of decrease in systolic function and progressing of dilatation of ventricles at patients with chronic heart failure (RAnversa, 1998)

Expressiveness of apoptosis in a myocardium directly correlates with rate of clinical progressing of a dilatatsionny cardiomyopathy (Saraste A. et al, 1999)

In experiment apoptosis managed to be suppressed inhibitors kaspaz and antioxidants (CookS., Poole-Wilson P., 1999)

 
"the Antitrombotichesky means applied in treatment of patients with coronary heart disease   Biventrikulyarny electrostimulation at chronic heart failure"