Anemia at Addison's illness was for the first time described by Addison in 1849. Anemia is moderately expressed, normotsitarny normokhromny type. Other changes in peripheral blood include a leukopenia with a relative lymphocytosis and an eosinophilia. Pernicious anemia can accompany Addison's illness, and in this case anemia can be macrocytic with megaloblastny changes in marrow. At the same time organospetsifichesky antibodies both to tissues of adrenal glands, and to covering cells of a mucous membrane of a stomach often are found. Level of serumal iron is normal, but iron utilization by erythrocytes is slightly reduced. The volume of plasma is also reduced that masks expressiveness of anemia.
The mechanism of development of anemia is not clear, but the adrenalectomy always leads to a hypoplasia of erythrocyte predecessors in marrow. Apparently, cortisol indirectly influences the erythrogenesis speed as administration of this substance causes increase in consumption of oxygen and the subsequent stimulation of production of erythropoetin.
Treatment of an adrenokortikosteroidama leads to gradual correction of anemia.