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Diphtheritic polyneuropathy, demyelinating poliradikulonevropatiya - Nervous diseases

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Nervous diseases
Anatomy of a nervous system
Peripheral nervous system
Vegetative nervous system
Brain covers, cerebrospinal liquid
Physiology of a nervous system
Blood supply of a head and spinal cord
Pathophysiological patterns of defeats of a nervous system
The anamnesis and the general survey in neurology
Neurologic survey
Tool methods of research in neurology
Spinal puncture
Motive disturbances
Extrapyramidal frustration
Sensitivity disturbances
Symptoms of defeat of a meninx
Disturbances of the highest brain functions
Vegetative frustration
Intracranial hypertensia
Syndromes of damage of a spinal cord
Pain syndromes at diseases of a nervous system
Secondary forms of a headache
Dorsodynia and extremities
Tservikalgiya and tservikobrakhialgiya
Lyumbalgiya and lumbar ishialgia
Diagnosis and treatment of a dorsodynia and extremities
Reflex sympathetic dystrophy
Vascular diseases of a nervous system, stroke
Treatment of a stroke in the acute period
Prevention of the subsequent stroke, rehabilitation
Acute hypertensive encephalopathy
Distsirkulyatorny encephalopathy
Disturbances of spinal blood circulation
Acute serous meningitis
Tubercular meningitis
Tick-borne encephalitis
Acute disseminated encephalomyelitis
Subacute sclerosing panencephalitis
Brain abscess
Prionny diseases
Neurologic displays of HIV infection
Brain parasitic diseases
Defeats of a vegetative nervous system
Vegetative crises
Neurogenic faints
Craniocereberal injury
Slight craniocereberal injury
Medium-weight and severe craniocereberal injury
Brain prelum
Effects of a craniocereberal injury
Vertebral and spinal injury
Treatment of epilepsy
Sleep disorders and wakefulnesses
Parkinson's illness
Essential tremor
Lateral amyotrophic sclerosis
Cerebellar degenerations
Family spastic paraplegia
Alzheimer's disease
Damages of cranial nerves
Giyen's syndrome — Barret
Diphtheritic polyneuropathy, demyelinating poliradikulonevropatiya
Multiple mononeuropathy
The surrounding herpes
Inflammatory myopathies
Metabolic myopathies
Disturbances of a neuromuscular transmission
Neural amyotrophy
Spinal amyotrophy
Defeat of a nervous system at intoxication alcohol
Neurologic complications of drug addiction
Poisonings with heavy metals
Poisoning with organophosphorous connections
Poisoning with carbon monoxide
Poisoning with methyl alcohol
Poisoning with medicines
Poisoning with bacterial toxins
Brain tumors
Tumors of a spinal cord
Kraniovertebralny anomalies
Malformations of a backbone and spinal cord
Diseases of a nervous system at children
Children's cerebral palsy
Hereditary neurometabolic diseases
Tics and Turett's syndrome
Defeats of a nervous system at somatopathies
Defeat of a nervous system at a diabetes mellitus
Paraneoplastic syndromes
Care of patients with paralyzes
Food of patients
Care of patients with disturbances of an urination, the prevention of injuries
Care of patients with dysfunction of a digestive tract
Care of patients in a coma, with disturbance of the speech, mentality
Rehabilitation of patients with diseases of a nervous system

Chronic inflammatory demyelinating poliradikulonevropatiya

The Chronic Inflammatory Demyelinating Poliradikulonevropatiya (CIDP) unlike Giyen's syndrome — Barret is characterized by slower development (the progressing phase usually proceeds not less than 2 months). Instructions on the previous infection occur at patients less often. More expressed sensitivity disturbances, including deep are usually noted, but the pain syndrome meets less often. Perhaps recurrent current, but is more often observed steady or stupeneobrazny progressing.
Treatment is begun with a plasma exchange or corticosteroids. At insufficient efficiency or bad portability of corticosteroids add a cytostatics (Azathioprinum, a methotrexate) or carry out the repeated courses of treatment including intravenous injections of immunoglobulin.

Diphtheritic polyneuropathy

The diphtheritic polyneuropathy arises under the influence of exotoxin which, getting into peripheral neurons, breaks myelin protein synthesis. Several weeks later there is demyelination of cranial nerves and nervous roots. The probability of development and weight of a polyneuropathy depend on expressiveness of toxicosis in an initial stage of a disease.

Clinical picture.

Symptoms of a diphtheritic neuropathy are often shown in a certain sequence. Paralysis of a soft palate, disturbance of sensitivity in a throat, decrease in a gag reflex develop in 3 — 4 weeks from the beginning of a disease. On 4 — the 5th week accommodation disturbance, on 5 — — paralysis of muscles of a throat, throat, a diaphragm appears the 7th week. At the same time there can be a damage of facial, acoustical nerves, a motive portion of a trifacial, additional and hypoglossal nerves.
The generalized polyneuropathy usually develops on 6 — the 12th week, is more often for the 50th day (the term from here — "a syndrome of the 50th day"). In the beginning there is paresis of feet, further weakness gradually extends to muscles of hips and a pelvic girdle, a muscle of hands and a trunk, including to respiratory muscles. Regarding cases disturbances of deep sensitivity with development of a sensitive ataxy prevail.
At a heavy polyneuropathy the lethal outcome which is usually connected with paralysis of respiratory or bulbar muscles or damage of heart is possible. At the survived patients recovery begins several days later or weeks from the moment of emergence of the first symptoms and usually takes from several weeks to several months.


Administration of anti-toxic serum in the acute period of an infection (especially in the first 48 h a disease) reduces probability and weight of neurologic complications. But during this period, when there are neurologic symptoms, specific therapy is already inefficient. The basis of treatment is made by the adequate supporting and symptomatic therapy. During recovery carry out remedial gymnastics, massage, electrostimulation.

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