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Endocrinology

Insufficiency of B6 vitamin

Insufficiency of B6 vitamin as a hypovitaminosis — the morbid condition caused by deficit of this vitamin B an organism and which is shown generally changes of a mucous membrane of an oral cavity, skin and the TsNS functions. The separate nosological form recognized as B6 avitaminosis is not allocated yet.

Epidemiology
The majority of cases of a hypovitaminosis of B6 at adults are secondary. Insufficiency of B6 vitamin is observed at pregnancy and a number of diseases: alcoholism, polyneuritis, parkinsonism, epilepsy, seborrheal dermatitis, anemias, rheumatism, chronic hepatitis, intoxication hydrazine connections, etc.

Pathogeny
B6 vitamin (pyridoxine) in an organism turns into piridoksal-5-phosphate and is a part of the enzymes participating in decarboxylation and transamination of amino acids, a histamine exchange, a lipometabolism. Deficit of B6 vitamin leads to weight loss, change of skin and its appendages, dysfunction of TsNS, anemia. At deficit of B6 vitamin transformation of tryptophane into niacin is broken that leads to pellagropodobny symptoms.

Classification
Classification of insufficiency of B6 vitamin is not developed.

Preliminary diagnosis
Unsharply expressed B6 hypovitaminosis forms meet. For diagnosis the same symptoms matter, as at a hyporiboflavinosis: a cheilosis, a glossitis, seborrheal dermatitis (mainly on a face), conjunctivitis. Note also deterioration in appetite, nausea.

Verification of the diagnosis
At B6 hypovitaminosis the content of 4-pyridoxynew acid in daily urine is lower than 0,5 mg, release of xanthurenic acid (after reception of 10 g of tryptophane) exceeds 50 mg. The maintenance of a piridoksii in whole blood is lower than 50 mkg/l or it is lower than 3,6 ng/ml of pyridoxal phosphate. These four parameters confirm B6 hypovitaminosis.

The same differential diagnosis, as at a hyporiboflavinosis. It is possible to distinguish these two forms of gipovitaminoz only by results of laboratory researches. In principle diagnosis ekh can help juvantibus.

Treatment and prevention
For the prevention of a hypovitaminosis of B6 the pyridoxine is appointed on 0,002 — 0,005 g a day. A medical dose (inside or parenterally) 0,05 — 0,1 g 2 times a day within 1 — 2 month. At sideroblastny anemia the pyridoxine is entered more often intramusculary on 0,1 g by 2 times a week, it is possible to appoint and inside 0,1 g daily. In case of long use of hydrazide of isonicotinic acid (isoniazid) and its derivatives (Ftivazidum, etc.) a pyridoxine is appointed preventively on 0,005 — 0,01 g/days.

 
"Insufficiency of B12 vitamin   Insufficiency of niacin"