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Close concepts: MRNPO syndrome (metastatic cancer at undetected primary tumor), metastatic cancer with unknown primary center, metastasises of an undetected tumor, a metastatic carcinoma with unknown localization of primary tumor
The Metastasises of Cancer of Unknown Primary Localization (MCUPL) represent one of the most important medical problems. Despite an extensive arsenal of the diagnostic means which are at the disposal of the doctor now this syndrome takes the 8th place among the most often found cancer options. In medical literature cases when, despite the most careful inspection, primary center did not manage to be found during lifetime, and sometimes and on opening were repeatedly described. Really, this syndrome belongs to extremely difficult diagnostic tasks: the doctor knows that he has to look for, however can not always find.
The syndrome of metastasises of cancer of unknown primary localization can be defined as the malignant disease which is shown the metastatic process confirmed with a biopsy without the revealed primary tumor. This definition is very indistinct. At what stage of inspection it is possible to conclude what primary tumor cannot be found? In literature there is no uniform answer to this question. In clinical practice the diagnosis metastasises of cancer of unknown primary localization is competent at a tumor metaotazirovaniye in a case when neither careful collecting the anamnesis, nor data of physical inspection and laboratory researches (including the general blood test, the analysis of urine, data of biochemical research and X-ray inspection of a thorax) found primary tumor.
Prevalence of metastasises of cancer of unknown primary localization
Metastasises of cancer of unknown primary localization meet more often than believe. Primary tumor remains unspecified at 10 — 15% of all cancer patients. Thus, this disease has big prevalence, than a leukosis, a multiple myeloma or Hodzhkin's illness.
Features of a tumor
Metastasises of cancer of unknown primary localization it is shown unusually, first of all it concerns distribution of metastasises. For example, emergence of metastasises in a liver at not affected bone tissue can be the first symptom of a prostate cancer.
Other feature of this syndrome is frequent localization of primary tumor in internals. So, the pancreatic cancer makes only 3% of all cases of cancer, nevertheless it is the most common cause of metastasises of cancer of unknown primary localization.