Beginning >> Diseases >> Endocrine >> Excess of estrogen

Endocrinology

Excess of estrogen

Estrogen - very important hormone for the woman's organism, necessary for normal functioning of reproductive system, forming and maintenance of secondary sexual characteristics. Estrogen is produced in ovaries, adrenal glands and other bodies, in an organism can be present at three forms: oestradiol, estrone, estriol.

Excess of estrogen, mainly oestradiol, often associate about estrogen domination, a state at which the content of estrogen in an organism of the woman can be insufficient, normal or raised, at at the same time existing deficit of progesterone.

Reasons.

Disturbance of a metabolism of estrogen towards its dominance can happen for many reasons:
1) Reception of synthetic hormonal drugs for the purpose of contraception or treatment (including diaphragms, condoms from a spermitsidama and vaginal gels).
2) Obesity. Fatty tissues possess own hormonal activity as contain in a large number enzyme aromatase which will transform the male sex hormones which are synthesized in adrenal glands to estrogen.
3) Contact with insecticides and phthalates. These chemicals hardly move to biochemical decomposition in environment and collect in tissues of the person. It is established that in addition to explicit cancerogenic action, they negatively influence hormonal and reproductive systems of a live organism. Insecticides come to fabrics at use of means for scaring away and extermination of insects (mosquitoes, ants, mites, etc.). Phthalates (are a part of plastic, paint and varnish products, washing and cosmetics) interact with receptors of estrogen and activate them therefore the raised estrogenic background forms.
4) Intake of artificial hormones with food. Modern producers of meat actively apply gormonosoderzhashchy drugs at cultivation of cattle and a bird. At the use in food of such meat hormones do not collapse, and are soaked up in blood and actively compete with own hormonal receptors of the person, special harm is received by ovaries, a uterus and mammary glands of women.
5) Smoking, excess alcohol intake.
6) Long depressions and stresses.
7) Deficit of nutrients. Vitamins and minerals are necessary for normal work of enzymatic system. The lack of some substances (selenium, provitamin A, lycopene, folic acid) leads to failures in its work.
8) Inadequate exercise stresses. The "sofa" way of life or, on the contrary, excessive loadings negatively influence the general metabolism including on synthesis of estrogen.
9) Diseases of a liver, zhelchevyvodyashchy ways and intestines. In a liver there is a linkng of estrogen with other substrates (sulfates and glucuronic acid) from where together with bile they come to intestines and leave in the natural way. At disturbances in work of a liver and zhelchevyvodyashchy ways estrogen remains to circulate in a free form. At a disbioza and the insufficient use of cellulose in intestines perhaps repeated absorption of estrogen in blood and increase in their total quantity in an organism.
10) Reception of some drugs. Antitubercular, the glucose-lowering drugs, antidepressants, barbiturates, drugs reducing acidity of a gastric juice (omeprazol) actively influence the general metabolism of estrogen.
In addition to the listed reasons of a giperestrogeniye can arise because of hormonedependent and tumoral diseases:
- syndrome of polycystic ovaries;
- androgensekretiruyushchy tumors of ovaries;
- hyper thecosis;
- pathologies of adrenal glands;
- estrogensekretiruyushchy tumors of ovaries;
- cysts of ovaries;
- HTG-sekretiruyushchiye tumors of any localization (vesical drift, choriocarcinoma, hypophysis adenomas, etc.);
- some diseases of a thyroid gland (autoimmune thyroiditis, hypothyroidism).

Symptomatology.

At early stages excess of estrogen is successfully compensated by internal resources of an organism, eventually there are various pathologies and disturbances, up to oncological diseases of a female genital. The first symptoms which can speak about a giperestrogeniya include:
- a nagrubaniye and morbidity of mammary glands during the premenstrual period;
- plentiful and long periods;
- intermenstrual bleedings;
- sharp mood swings.
These signs are not characteristic only of excess of estrogen, for exact diagnosis it is necessary to resort to laboratory and hardware methods of research.

Diagnosis.

For statement of the diagnosis blood test on the level of the following hormones is indicative: oestradiol, DEA-SO4, FSG, LG, TTG, testosterone, is also recommended ultrasonography of bodies of a small pelvis and cytologic research of scraping from a mucous neck of uterus. Biomaterial gets in certain days twice for a cycle. The following signs indicate a giperestrogeniya:
- vulval smear of proliferative type;
- pupil symptom (++++);
- basal temperature monophase;
- the kariopiknotichesky index has stable high rates;
- hyperplasia of an endometria of ferruterous type.

Treatment

Treatment depends on the reason of excess of estrogen. In the absence of serious pathology good results are yielded by normalization of work and rest, fight against addictions, a moderate exercise stress in combination with food normalization. The diet with enough protein, cellulose, vitamins and vegetable antioxidants is shown. As specific food additives soy flavonida are recommended. If it is not enough these methods, resort to medicamentous therapy: appoint anti-oestrogenic drugs (Tamoxifenum) or progesterone on a cycle.
At serious pathologies treat a basic disease.

 
"The slowed-down puberty   Mucoviscidosis"