Page 1 of 2
The enteroviral diseases caused by Koksaki's viruses and ECHO differ in polymorphism of clinical manifestations.
Etiology. Activators — Koksaki's viruses and ECHO. Now 30 serotypes of viruses of Koksaki are known: 24 — groups D and 6 — groups B. Some immunological types of viruses of Koksaki cause damage of a brain, others, such as A14, A16, were kardiotropny. The ECHO viruses 24 types are allocated. At infection with viruses of ECHO group there can be various neurologic syndromes, in particular paralyzes of peripheral type at children.
Epidemiology. An infection source — patients and virus carriers. The transfer mechanism airborne and fecal and oral, a disease is transmitted also through the contaminated objects and insects (flies and cockroaches). The activator is allocated in environment mainly with a stake, at aseptic meningitis and a herpangina — with a phlegm. Viruses find also in blood, cerebrospinal fluid and in nasopharyngeal washouts of patients. In the flying and in the fall during epidemic flashes considerable specific weight is made by cases of the erased and latent course of an infection.
Pathogeny. Entrance infection atriums is the mucous membrane of nasal part of a throat and a small bowel, in an epithelium and which lymphatic educations there is primary reproduction of enteroviruses. Then the virus gets into a blood flow and causes a virusemia. From blood the activator gets to various bodies and fabrics. There are incontestable proofs of pre-natal infection and the instruction on what entsefalomiokardit is the reason of sudden death at small children.
Clinic. Clinical manifestations at an enteroviral infection are various: from asymptomatic and slight diseases to heavy entsefalomiokardit with a lethal outcome. Clinical syndromes of an illness can be combined. They are characterized by a short incubation interval — to 10, is rare — 14 days, the acute beginning with high temperature, a short-term current, frequent recurrence. On the leading signs clinical options can be observed: the herpangina, "a small illness", a pleurodynia, serous meningitis, entsefalomiokardit, perikardita and myocardites, an enteroviral dieback, acute hemorrhagic conjunctivitis, respiratory enteroviral diseases, enteroviral diarrhea.