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Differential diagnosis of premature sexual development

At boys:

True premature sexual development:
pubertal basal level of gonadotrophins
pubertal stimulated LG-RG level of gonadotrophins, mainly LG
pubertal level of testosterone
the sizes of testicles correspond to normal puberty
in the presence of volume education - characteristic KT and/or the MR-picture
Chorionic gonadotrophin - the cosecreting tumors
the LG high levels, the determined by RIA method and chorionic gonadotrophin
lack of the response of LG to stimulation of LG-RG
pubertal level of testosterone
small increase in testicles
Peripheral premature sexual development
1. Tumors of testicles
low basal level of gonadotrophins
lack of the response of gonadotrophins to stimulation of LG-RG
very high level of testosterone
unilateral increase in a small egg
2. Testotoksikoz
low basal level of gonadotrophins
lack of the response of gonadotrophins to stimulation of LG-RG
pubertal or very high level of testosterone
the size of testicles is more than dopubertatny norm, but it is less than stage of sexual development, unilateral or bilateral adenomatosis is possible

At girls:

True premature sexual development:
pubertal basal level of gonadotrophins
pubertal response of gonadotrophins to stimulation of LG-RG, mainly LG
increase in ovaries and uterus
in the presence of volume formation of TsNS - characteristic KT or the MR-picture

Peripheral premature sexual development
Granulocellular tumors of ovaries
low basal level of gonadotrophins
lack of the response of gonadotrophins to stimulation of LG-RG
very high level of oestradiol
increase in an ovary at physical, ultrasonic and MRT-research

Follicular cysts
low basal level of gonadotrophins
dopubertatny character of the response of LG to stimulation LG-RG, but character of the answer of FSG can be pubertal
level of oestradiol can be both low, and high depending on the size of ovarian cysts
ultrasonic research reveals existence of ovarian cysts.

 
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