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Introduction - Tsikloferon in treatment of diseases of the infectious nature

Table of contents
Introduction
Pharmacokinetics
Meningitis
Herpes
Viral hepatitis
HIV/AIDS
Clamidiosis
Treatment of clamidiosis

Now growth of separate nosological forms of infectious diseases, first of all, of viral infections is noted. One of the directions of improvement of methods of treatment – use of interferon, as important nonspecific factors of antiviral resistance. Which treats tsikloferon - the low-molecular synthetic inductor of endogenous interferon.

Originators
Rudenko A.A. - Honored doctor of Ukraine, doctor of medical sciences, chief infectiologist of the Ministry of Health of Ukraine

Vovk A.D., Bobrova I.A., Muravskaya L.V., Shevchuk V. B., Birchbark T.G., Shantyr E.E., - candidates of medical sciences

Antonyak See - the research associate

Kotsyuba E.E., Reznik V.A., Zaginayko V. F. - infectiologists

Reviewer:
Kramarev S. A., MD, professor

Now growth of separate nosological forms of infectious diseases is noted. It concerns, first of all, viral infections. WHO declared epidemic of a herpes infection in the world, increase of cases of the meningoentsefalit of the virus nature including caused by influenza viruses, a parainfluenza, respiratory and syncytial, adenoviruses, enteroviruses, etc. is observed.

Incidence of a viral hepatitis remains at the high level. Prompt growth of HIV infection (AIDS) is observed. A significant amount of diseases of the urogenital sphere disturbs. Treatment of the listed diseases differs in complexity, not always happens successful. Often inefficiency of therapy leads to an invalidism of patients, and sometimes and by lethal outcomes. Proceeding from told, improvement of the existing methods of treatment and development new are one of health care priorities. In recent years it is paid much attention to nonspecific resistance of an organism. An important role in it is played by the interferona and inductors of their endogenous synthesis which are carrying out the broad control regulating functions directed to preservation of a cellular homeostasis. The most important of them are anti-virus, immunomodulatory and radio protective function.

Interferona are factors of the proteinaceous nature with a molecular weight of 20000-30000 and specific activity which equals or exceeds 10 on 1 mg of protein. Interferona in vitro and in vivo in response to influence of natural and synthetic inductors are synthesized, affect intracellular processes of a reproduction of considerable number of RNA and DNA-containing of viruses, inhibiting broadcast of virus information RNA and their biosynthesis and suppressing reproduction of the fast-sharing cells.

Natural inductors of interferon are viruses, endotoxins, intracellular parasites, etc. Among numerous synthetic inductors of interferon (it is high - and low-molecular) the most active are double-stranded polynucleotides weed (And) • weed (C). Studying of a complex of the called polynucleotides allowed to decipher patterns of products of interferon.

Clinical use of interferon and its inductors represents one of actual problems of medicine so far. Being an important nonspecific factor of antiviral resistance, interferon is produced right after hit of a virus in an organism, but for the prevention of development of an infectious disease of naturally formed interferon happens insufficiently especially as a number of viruses oppresses products of endogenous interferon. There are two main approaches to use of interferon at viral diseases - administration of ready drugs exogenous and induction of production of own endogenous interferon. At the majority of viral infections direct correlation between the content of interferon in blood and disease severity is established. At heavy disease the interferon level, and also interferon - the producing ability of cells of mononuklearno-phagocytal system decreases, and at a lung - increases. Us it is accurately shown on the example of patients with flu uncomplicated and at complication by pneumonia. In
case of lethal outcomes interferon credits in blood of the dead from pneumonia were zero. Use of ready drugs of highly active human interferon was effective, but their production - expensive and difficult. Other method of treatment of diseases of the virus nature which does not concede to administration of exogenous interferon is the induction of own (endogenous) interferon. At induction highly active hozyaino-specific interferon in which products various cells and body tissues take active part is formed. At the same time also other mechanisms of nonspecific resistance are stimulated (phagocytosis, antibody formation, system of a complement, etc.). The optimum drug inducing interferon has to be highly active, non-toxic, stable, rather cheap, not possess antigenicity.

Possesses many of these qualities tsikloferon - the low-molecular synthetic inductor of endogenous interferon possessing ability to cause education and - β-and at-interferonov in an organism. Drug is derivative a 10-carboxymethylene-9-aktidanona (akridonuksusny acid) about N-methyl-glyukaminom. Derivatives of akridonuksusny acid possess a hypotoxicity, lack of allergenic, mutagen and embriotoksichesky action on an organism, and also metabolic splitting in a liver and a kumulirovaniye in an organism. For the first time antiviral activity of akridonuksusny acid and its derivatives was established by the American researchers in 1972 - sodium salt of akridonuksusny acid showed the high level of protection against viruses of the wood of Semliki, the western and east encephalitis, flu and herpes. It is established later that antiviral activity of akridonuksusny acid concerning a wide range of viruses is caused by induction in an organism of high credits of endogenous interferon and that exclusively immunocompetent cells of an organism possess ability to induce interferon under the influence of salt of akridonuksusny acid: monocytes, macrophages, lymphocytes, Kupferova of a liver cell. Tsikloferon begins to induce early interferon in 4-8 hours, the peak is reached at 18 o'clock, gradual decrease goes by 24 o'clock from the moment of administration of drug. All inductors of interferon cause education of the last in a liver, at induction tsikloferony interferon is synthesized also in brain fabric.

Tsikloferon has no contraindications. It is applied at a herpes infection, HIV, hepatitises, clamidiosis, virus neuroinfections, etc.

Inductors of interferon have a certain advantage over drugs of exogenous interferon: at their introduction the interferon which is not possessing antigenicity is produced; there are no negative effects inherent in drugs of exogenous interferon; potential pyrogenicity and allergenicity, danger of emergence of autoimmune processes is limited. Synthesis of the induced interferon in an organism is balanced and is exposed to the control and regular mechanisms (repressotranslyation) providing protection of an organism against oversaturation with interferon.

Single introduction of inductors of interferon provides rather long circulation of endogenous interferon.


 
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