Bazalioma (basal and cellular epithelioma). The tumor which is localized more often on face skin with "an optional zlokachestvennost": in most cases has a long chronic current, seldom metastasizes (however can recur, get destruktiruyushchy growth). At timely begun treatment of 85 — 90% of patients recover. Some bazalioma develop, apparently, on the basis of genetic predisposition and can be combined with anomalies of development.
Most widely apply a method of radical removal of a bazalioma — excision of a tumor with capture not less than 0,5 cm of the skin surrounding a tumor with the subsequent plastics a free transplant. I. Mohs offered a method of layer-by-layer removal of a bazalioma (under the general anesthesia) with histologic research of each layer that gives the most exact idea of tumor borders ("microscopically controlled surgery"). At prevalence of process and tendency to recurrence carry out postoperative radiation. The chemotherapy after operation, especially at widespread bazalioma, is ineffective and can serve only as "additional load" of an organism (V. Fisch and soavt., 1981).
Small superficial and multiple flat bazalioma of a trunk, especially at elderly people, it is possible to cauterize special electrodes with use of high-frequency alternating current. This type of treatment is not applied at recurrent, deep, superficial widespread, sklerodermiformny bazalioma. Use electroscission as one of stages of the combined treatment of tumors (for example, after radiation therapy) including in a late stage of process.
Radiation therapy is applied if it is impossible to remove a tumor considerably: the weakened patient, especially senile age, at widespread process, disturbance of anti-coagulative properties of blood, tendency to keloids, not completely excised tumor, recurrence after other methods of treatment. The short-distance roentgenotherapy is carried out more often by a fractional method on 52 — 129 mkl/kg on a session, daily, in a total dose 774 — 1290 mkl/kg. At elderly people with localization of a bazalioma on a face it is possible to apply myagkoluchevy therapy. Beam treatment do not carry out to persons of young age, at the bleeding tumors, ulcus terebrans, a sklerodermiformny bazalioma, basal and cellular a nevus syndrome, multiple bazalioma, injuries of skin.
Topical administration of cytostatic drugs is shown at superficial, recurrent, nevoid, bazalioma, development of tumors difficult available to other methods of treatment on site of x-ray radiation, and also at disturbance of anti-coagulative properties of blood.
Considerable difficulties arise at treatment bazaliy, the eye which are localized in the field of corners, an internal surface of an auricle, on centuries where use of laser radiation, surgical excision, a cryolysis, chemotherapy is difficult or contraindicated. And rather effective introduction to the center of defeat and sites of skin of human leukocytic interferon, adjacent to it, injection is more sparing (within 10 days): at superficial bazalioma — on 2500 ME 2 time a day, on a course of 50 000 ME, at cystous, ulcer, adenoid forms — on 5000 ME 2 time a day, on a course 75 000 — 100 000 ME (B. A. Berenbeyn and soavt., 1985).
According to B. A. Berenbeyn (1985), are most effective at treatment of a precancerous dermatosis and epithelial new growths of skin small doses of cytostatic drugs (Prospidinum, Spirobrominum, cyclophosphamide) in combination with a superficial cryolysis, an obkalyvaniye of the centers of defeat by the interferon and drugs normalizing the level of cyclic nucleotides.
Supervision of the oncologist-dermatologist, restriction of impact on skin of adverse external factors — physical (excessive insolation, the ionizing radiation, burns, an intermittent trauma), chemical are shown (pitches, tar, creosote, etc.).